8-Hydroxydeoxyguanosine as a Useful Marker for Determining the Severity of Trichloroethylene Exposure
Archives of Environmental and Occupational Health, cilt.69, sa.3, ss.180-186, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69 Sayı: 3
- Basım Tarihi: 2014
- Doi Numarası: 10.1080/19338244.2013.763761
- Dergi Adı: Archives of Environmental and Occupational Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.180-186
- Anahtar Kelimeler: oxidative stress, severity, trichloroacetic acid, workers, OXIDATIVE STRESS, WORKERS, DAMAGE, MICE
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
The aim of this study was to determine 8-hydroxydeoxyguanosine (8-OH-dG) levels in trichloroethylene (TCE)-exposed workers. Oxidative stress biomarkers and biochemical parameters were monitored among 26 TCE-exposed workers and 78 age-matched control subjects. Levels of urinary 8-OH-dG were analyzed by liquid chromatography tandem mass spectrometry. Urinary 8- OH-dG levels were significantly higher for TCE-exposed group (p < .001). Spearman's correlation test revealed positive correlations between urinary trichloroacetic acid levels and age, urinary 8-OHdG, urinary total oxidant status, and urinary total antioxidant status (p = .042, p < .001, p < .001, and p < .001, respectively). 8-OH-dG may be a useful marker to determine the extent of TCE exposure. © 2014 Taylor & Francis Group, LLC.