8-Hydroxydeoxyguanosine as a Useful Marker for Determining the Severity of Trichloroethylene Exposure

Abusoglu S., Celik H. T., Tutkun E., Yilmaz H., Serdar M. A., Bal C. D., ...More

Archives of Environmental and Occupational Health, vol.69, no.3, pp.180-186, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1080/19338244.2013.763761
  • Journal Name: Archives of Environmental and Occupational Health
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.180-186
  • Keywords: oxidative stress, severity, trichloroacetic acid, workers, OXIDATIVE STRESS, WORKERS, DAMAGE, MICE
  • Lokman Hekim University Affiliated: No

Abstract

The aim of this study was to determine 8-hydroxydeoxyguanosine (8-OH-dG) levels in trichloroethylene (TCE)-exposed workers. Oxidative stress biomarkers and biochemical parameters were monitored among 26 TCE-exposed workers and 78 age-matched control subjects. Levels of urinary 8-OH-dG were analyzed by liquid chromatography tandem mass spectrometry. Urinary 8- OH-dG levels were significantly higher for TCE-exposed group (p < .001). Spearman's correlation test revealed positive correlations between urinary trichloroacetic acid levels and age, urinary 8-OHdG, urinary total oxidant status, and urinary total antioxidant status (p = .042, p < .001, p < .001, and p < .001, respectively). 8-OH-dG may be a useful marker to determine the extent of TCE exposure. © 2014 Taylor & Francis Group, LLC.