Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat
Seizure, cilt.18, sa.6, ss.396-399, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 6
- Basım Tarihi: 2009
- Doi Numarası: 10.1016/j.seizure.2009.02.003
- Dergi Adı: Seizure
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.396-399
- Anahtar Kelimeler: Oxcarbazepine, Valproic acid, Retinal ganglion cell, COLOR-VISION, ANTIEPILEPTIC DRUGS, ADOLESCENTS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number. © 2009 British Epilepsy Association.