Retinal ganglion cell toxicity due to oxcarbazepine and valproic acid treatment in rat

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Aktaş Z., Cansu A., Erdoǧan D., Take G., Goktas G., ÖZDEK Ş., ...More

Seizure, vol.18, no.6, pp.396-399, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1016/j.seizure.2009.02.003
  • Journal Name: Seizure
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.396-399
  • Keywords: Oxcarbazepine, Valproic acid, Retinal ganglion cell, COLOR-VISION, ANTIEPILEPTIC DRUGS, ADOLESCENTS
  • Lokman Hekim University Affiliated: No


Purpose: To evaluate and to compare the possible toxic effects of oxcarbazepine (OXC) and valproic acid (VPA) on retinal ganglion cells (RGCs) in rat. Methods: Forty female Wistar rats (21-24 days old and weighted between 44.6 and 57.3 g) were divided equally into 4 experimental groups which were applied tap water (group 1), 300 mg/(kg day) VPA (group 2), 100 mg/(kg day) OXC (group 3), and both VPA and OXC (group 4) via gavage for 90 days. Enucleation was performed for histopathologic analysis. RGCs were counted under the light microscopic examination. Results: RGC numbers in OXC and combined OXC-VPA groups were found to be lower than those of control group. On the other hand RGC number was comparable with those of control group in VPA group. Conclusion: OXC seems to be toxic to RGCs at 100 mg/kg dose when it is been given as a monotherapy or combined with VPA. Single VPA treatment has no effect on RGC number. © 2009 British Epilepsy Association.