Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice

Altay, Orhan; Suzuki, Hidenori; Hasegawa, Yu; Altay, Bilge; Tang, Jiping; Zhang, John

doi:10.1016/j.neulet.2020.134979

Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice

Altay O., Suzuki H., Hasegawa Y., Altay B. N., Tang J., Zhang J. H.

NEUROSCIENCE LETTERS, cilt.728, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 728
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.neulet.2020.134979
Dergi Adı: NEUROSCIENCE LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: apoptosis, early brain injury, heparin, sphingosine kinase, subarachnoid hemorrhage, SPHINGOSINE 1-PHOSPHATE, ENDOTHELIAL-CELLS, SPHINGOSINE-1-PHOSPHATE RECEPTORS, THROMBIN, EXPRESSION, LIPASE, ACTIVATION, ADHESION, HEALTH, KINASE
Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Background: Sphingosine kinase (SphK) 1 has been reported as an important signaling node in anti-apoptotic signaling. Heparin is a pleiotropic drug that antagonizes many pathophysiological mechanisms. In this study, we evaluated if heparin prevents early brain injury (EBI) after subarachnoid hemorrhage (SAH) by anti-apoptotic mechanisms including SphK1.