Effects of low-dose unfractionated heparin on early brain injury after subarachnoid hemorrhage in mice

Altay O., Suzuki H., Hasegawa Y., Altay B. N., Tang J., Zhang J. H.

NEUROSCIENCE LETTERS, vol.728, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 728
  • Publication Date: 2020
  • Doi Number: 10.1016/j.neulet.2020.134979
  • Journal Name: NEUROSCIENCE LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: apoptosis, early brain injury, heparin, sphingosine kinase, subarachnoid hemorrhage, SPHINGOSINE 1-PHOSPHATE, ENDOTHELIAL-CELLS, SPHINGOSINE-1-PHOSPHATE RECEPTORS, THROMBIN, EXPRESSION, LIPASE, ACTIVATION, ADHESION, HEALTH, KINASE
  • Lokman Hekim University Affiliated: No

Abstract

Background: Sphingosine kinase (SphK) 1 has been reported as an important signaling node in anti-apoptotic signaling. Heparin is a pleiotropic drug that antagonizes many pathophysiological mechanisms. In this study, we evaluated if heparin prevents early brain injury (EBI) after subarachnoid hemorrhage (SAH) by anti-apoptotic mechanisms including SphK1.