Evaluation of the evectiveness of topical ciproxoxacin and prednisolone in the prevention of myringosclerosis


Arslan N., Tepe D., Taotan E., Demirci M., Caydere M., Ustun H., ...More

European Archives of Oto-Rhino-Laryngology, vol.269, no.11, pp.2335-2341, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 269 Issue: 11
  • Publication Date: 2012
  • Doi Number: 10.1007/s00405-011-1889-z
  • Journal Name: European Archives of Oto-Rhino-Laryngology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2335-2341
  • Keywords: Myringosclerosis, Tympanosclerosis, Ciprofloxacin, Corticosteroid, Rat, TYMPANIC MEMBRANES, MIDDLE-EAR, TYMPANOSCLEROSIS, RAT, CELLS, DEXAMETHASONE, MYRINGOTOMY, INHIBITION, EXPRESSION, HISTOLOGY
  • Lokman Hekim University Affiliated: No

Abstract

An antibacterial drug, ciproXoxacin, has been reported to modulate the inXammatory and immune responses on monocytes. Our objective is to evaluate the eVectiveness of ciproXoxacin in the prevention of myringosclerosis that is created by myringotomy in rats and to compare it with prednisolone. In this study, 24 healthy Sprague- Dawley type rats of age 3-4 months and 250-300 g weight were used. Rats have been divided into three random groups. Topical ciproXoxacin was administered to the rats in the Wrst group and topical prednisolone was administered to the rats in the third group; no medication was applied to their opposite ears and they were determined as control group. Prednisolone was administered to one ear of the rats and ciproXoxacin was administered to their opposite sides in the second group. After bilateral myringotomies the treatments were applied for 20 days as Wve drops two times a day. Otomicroscopic examination was made on the 10th day and reperforations were made when necessary. Rats were killed on the 21st day and temporal bone dissections were done. When we evaluate in terms of myringosclerosis and tympanic membrane thickness, in the Wrst group, myringosclerosis and thickness have been observed in two of seven ears (28.6%) where ciproXoxacin was administered and in Wve of the seven ears (71.4%) where no treatment was applied. In the second group where prednisolone and ciproXoxacin were compared, myringosclerosis and thickness have been observed in six of the ten ears (60.0%) where prednisolone was administered and in four of the ten ears (40.0%) where ciproXoxacin was administered. In the third group, myringosclerosis and thickness have been observed in three of seven ears (42.9%) where prednisolone was administered and in four of the seven ears (57.1%) where no treatment was applied. All histopathological evaluations were made by one pathologist in a blinded manner. In our study, the eVect of the ciproXoxacin and prednisolone was similar in preventing the experimental myringosclerosis and TM thickness in rats. When compared with the control groups, this preventive eVect was more obvious in the cipro- Xoxacin treatment group than that of prednisolone. © Springer-Verlag 2011.