Investigation of double-carbapenem efficiency in experimental sepsis of colistin-resistant <i>Klebsiella pneumoniae</i>.


Kosar I., DİNÇ G., Eren E., Aykemat Y., Kilic M., Kilic H., ...More

Northern clinics of Istanbul, vol.8, no.2, pp.113-118, 2021 (Refereed Journals of Other Institutions) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.14744/nci.2020.14238
  • Title of Journal : Northern clinics of Istanbul
  • Page Numbers: pp.113-118
  • Keywords: Coastal resistance, experimental sepsis, Klebsiella pneumoniae, BLOOD-STREAM INFECTIONS, IN-VITRO ACTIVITY, MOLECULAR EPIDEMIOLOGY, COMBINATION, MEROPENEM, TIGECYCLINE, ERTAPENEM

Abstract

OBJECTIVE: Klebsiella pneumoniae, a Gram-negative pathogen, especially which produces carbapenemase, is seen as a major threat to public health due to rapid plasmid-mediated spread of resistance and limited therapeutic options available for treatment. Although colistin has been recognized as a "last resort" antimicrobial for multidrug-resistant K. pneumoniae infections, these isolates have developed resistance to colistin as a result of its intensive use. The aim of this study was to evaluate the efficacy of double-carbapenem treatment of colistin-resistant K. pneumoniae experimental sepsis in mice.