Investigation of double-carbapenem efficiency in experimental sepsis of colistin-resistant <i>Klebsiella pneumoniae</i>.

Kosar I., DİNÇ G., Eren E., Aykemat Y., Kilic M., Kilic H., ...Daha Fazla

Northern clinics of Istanbul, cilt.8, sa.2, ss.113-118, 2021 (Hakemli Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.14744/nci.2020.14238
  • Dergi Adı: Northern clinics of Istanbul
  • Sayfa Sayıları: ss.113-118
  • Anahtar Kelimeler: Coastal resistance, experimental sepsis, Klebsiella pneumoniae, BLOOD-STREAM INFECTIONS, IN-VITRO ACTIVITY, MOLECULAR EPIDEMIOLOGY, COMBINATION, MEROPENEM, TIGECYCLINE, ERTAPENEM
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Klebsiella pneumoniae, a Gram-negative pathogen, especially which produces carbapenemase, is seen as a major threat to public health due to rapid plasmid-mediated spread of resistance and limited therapeutic options available for treatment. Although colistin has been recognized as a "last resort" antimicrobial for multidrug-resistant K. pneumoniae infections, these isolates have developed resistance to colistin as a result of its intensive use. The aim of this study was to evaluate the efficacy of double-carbapenem treatment of colistin-resistant K. pneumoniae experimental sepsis in mice.