The cardiopulmonary effects of the calcitonin gene-related peptide family Kalsitonin-geni ile ilişkili peptit ailesinin kardiyopulmoner etkileri

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TELLİ G., TEL B. C. , Gumusel B.

Turkish Journal of Pharmaceutical Sciences, vol.17, no.3, pp.349-356, 2020 (Refereed Journals of Other Institutions) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.47123
  • Title of Journal : Turkish Journal of Pharmaceutical Sciences
  • Page Numbers: pp.349-356
  • Keywords: CGRP family, cardiopulmonary diseases, adrenomedullin, adrenomedullin2, intermedin, pulmonary hypertension, VASCULAR SMOOTH-MUSCLE, PULMONARY ARTERIAL-HYPERTENSION, ACTIVITY-MODIFYING PROTEINS, INCREASED PLASMA-LEVELS, CENTRAL-NERVOUS-SYSTEM, NITRIC-OXIDE, REGIONAL HEMODYNAMICS, SIGNAL-TRANSDUCTION, ENDOTHELIAL-CELLS, DEPENDENT PATHWAY

Abstract

© Turk J Pharm Sci, Published by Galenos Publishing House.Cardiopulmonary diseases are very common among the population. They are high-cost diseases and there are still no definitive treatments. The roles of members of the calcitonin-gene related-peptide (CGRP) family in treating cardiopulmonary diseases have been studied for many years and promising results obtained. Especially in recent years, two important members of the family, adrenomedullin and adrenomedullin2/intermedin, have been considered new treatment targets in cardiopulmonary diseases. In this review, the roles of CGRP family members in cardiopulmonary diseases are investigated based on the studies performed to date.