Relationship between tear eotaxin-2 and MMP-9 with ocular allergy and corneal topography in keratoconus patients

Mutlu M., SARAÇ Ö., ÇAĞIL N., Avcıoğlu G.

International Ophthalmology, vol.40, no.1, pp.51-57, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1007/s10792-019-01149-x
  • Journal Name: International Ophthalmology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.51-57
  • Keywords: Keratoconus, MMP-9, Eotaxin-2, Seasonal allergic conjunctivitis, Corneal topography, HUMAN EOSINOPHIL, EXPRESSION, KERATOCONJUNCTIVITIS, 0.05-PERCENT, MECHANISMS, CYTOKINES, MEDIATORS, SEVERITY
  • Lokman Hekim University Affiliated: No


© 2019, Springer Nature B.V.Purpose: To analyze the relationship between the seasonal allergic conjunctivitis (SAC), eotaxin-2, matrix metalloproteinase-9 (MMP-9), and the topographical findings in the keratoconus patients. Methods: Thirty-four eyes of patients without SAC (Group 1), 34 eyes of patients with SAC (Group 2), and 20 eyes of control subjects (control group) were enrolled. Tear samples of the subjects were collected by Schirmer method. Corneal topography parameters, tear MMP-9, and tear eotaxin-2 levels were analyzed. Results: The mean tear MMP-9 levels in Groups 1 and 2 were significantly higher than in the control group (p = 0.004). MMP-9 level exhibited a positive correlation with the keratoconus stage and a negative correlation with the thinnest corneal thickness (r = 0.294, p = 0.018, and r = − 0.302, p = 0.006, respectively). The tear eotaxin-2 level was higher in Group 2 than in Group 1 and control group which is not statistically significant (p = 0.17). Conclusion: The tear eotaxin-2 did not exhibit any difference in the presence of keratoconus. The tear MMP-9 level was higher in the keratoconic eyes, and it showed a correlation with the stage of the disease and the corneal thickness.