Vitamin D replacement effect on platelet counts

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Küçükay M. B. , Alanlı R.

Journal of the College of Physicians and Surgeons Pakistan, vol.31, no.9, pp.1064-1068, 2021 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.29271/jcpsp.2021.09.1064
  • Journal Name: Journal of the College of Physicians and Surgeons Pakistan
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.1064-1068
  • Keywords: Blood platelet count, Complete blood count, Vitamin D


© 2021 College of Physicians and Surgeons Pakistan. All rights reserved.Objective: To determine the effect of vitamin D treatment on platelet counts according to age groups in patients with vitamin D deficiency. Study Design: An observational study. Place and Duration of Study: Outpatient Clinics, Department of Internal Medicine, Faculty of Medicine, Lokman Hekim University Hospital, Ankara, Turkey from January 1st to December 31st, 2020. Methodology: A total of 1,230 participants, who were treated for vitamin D deficiency after admission to hospital for various reasons, were enrolled. Patients under 18 years of age, having chronic diseases, using medicines affecting platelets and who had 25-hydroxyvitamin D levels above 74.88 nmol/L were excluded from study. Participants were divided into three groups according to ages: 18 to 30 (Group 1), 30 to 50 (Group 2), and greater than 50 years (Group 3). Complete blood count parameters and vitamin D level data before and after vitamin D replacement treatment were compared. Results: Platelet counts and mean platelet volume levels were found to be significantly lower in participants after vitamin D treatment. Changes in hemoglobin and neutrophil counts were insignificant. Although there was no difference between mean platelet counts and age groups before treatment, significant differences were noted after vitamin D treatment (p=0.004). Correlation between vitamin D levels and changes in platelet levels compared to treatment beginning was found to be significant (r=-0.159, p<0.001). Conclusion: Vitamin D treatment lowered platelet counts. This may be beneficial in medical conditions such as essential thrombocythemia in which platelet counts are higher than normal, and may help decrease platelet counts.