Akademik Veri Yönetim Sistemi
Proceedings of the 1996 3rd Biennial Joint Conference on Engineering Systems Design and Analysis, ESDA. Part 7 (of 9), Montpellier, Fransa, 1 - 04 Temmuz 1996, cilt.77, ss.113-116
Combined deficiency of selenium and vitamin E leads to cardiovascular abnormalities, skeletal muscle dystrophy, nail abnormalities, and Koshin Beck disease which is an endemic and chronic degenerative osteoarthrosis. The abnormalities can be reversed by the administration of various forms of selenium and vitamin E. However, there is a narrow margin between safe therapeutic and toxic doses. It has been shown that large doses of selenium compound have cytotoxic effects on several tissues via the oxidation of protein thiols. The present study was designed to investigate and compare the effects of dietary selenium and vitamin E on the biomechanical properties of bone and skeletal muscle. Both sex young rabbits were fed with either a standardized vitamin E and selenium adequate diet, a selenium and vitamin E deficient diet or a selenium rich diet. Deficiency or excess of selenium was verified by direct methods (tissue and blood selenium analyses). The biomechanical properties of bones and muscles from these three groups were determined experimentally with tension and bending tests. Although it has been pointed out that selenium is a highly toxic agent and caution has to be taken, this can not be an overriding objection against supplementation of the diet with low doses of selenium.