Nanofibers based antibacterial drug design, delivery and applications


ULUBAYRAM K., ÇALAMAK S., Shahbazi R., Eroglu I.

Current Pharmaceutical Design, cilt.21, sa.15, ss.1930-1943, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 15
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1381612821666150302151804
  • Dergi Adı: Current Pharmaceutical Design
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1930-1943
  • Anahtar Kelimeler: Antimicrobial agents, nanofibers, electrospinning, nanodecorated fiber, fiber design, drug delivery, CONTROLLED-RELEASE, POLYACRYLONITRILE NANOFIBERS, TETRACYCLINE HYDROCHLORIDE, ELECTROSPUN NANOFIBERS, ANTIMICROBIAL PEPTIDES, COMPOSITE NANOFIBERS, SUSTAINABLE DELIVERY, POLYMER NANOFIBERS, CELLULOSE-ACETATE, IN-VITRO
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2015 Bentham Science Publishers.Infections caused by microorganisms like bacteria, fungi, etc. are the main obstacle in healing processes. Conventional antibacterial administration routes can be listed as oral, intravenous/intramuscular, topical and inhalation. These kinds of drug administrations are faced with critical vital issues such as; more rapid delivery of the drug than intended which can result in bacterial resistance, dose related systemic toxicity, tissue irritation and finally delayed healing process that need to be tackled. Recently, studies have been focused on new drug delivery systems, overcoming resistance and toxicological problems and finally localizing the molecules at the site of action in a proper dose. In this regard, many nanotechnological approaches such as nanoparticulate therapeutic systems have been developed to address accompanying problems mentioned above. Among them, drug loaded electrospun nanofibers propose main advantages like controlled drug delivery, high drug loading capacity, high encapsulation efficiency, simultaneous delivery of multiple drugs, ease of production and cost effectiveness for pharmaceutical and biomedical applications. Therefore, some particular attention has been devoted to the design of electrospun nanofibers as promising antibacterial drug carrier systems. A variety of antibacterials e.g., biocides, antibiotics, quaternary ammonium salts, triclosan, metallic nanoparticles (silver, titanium dioxide, and zinc oxide) and antibacterial polymers (chitosan, polyethyleneimine, etc.) have been impregnated by various techniques into nanofi-bers that exhibit strong antibacterial activity in standard assays. This review highlights the design and delivery of antibacterial drug loaded nanofibers with particular focus on their function in the fields of drug delivery, wound healing, tissue engineering, cosmetics and other biomedical applications.