Synthesis and antistaphylococcal activity of N-substituted-1H- benzimidazole-sulphonamides
Archiv der Pharmazie, cilt.343, sa.1, ss.31-39, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 343 Sayı: 1
- Basım Tarihi: 2010
- Doi Numarası: 10.1002/ardp.200900199
- Dergi Adı: Archiv der Pharmazie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.31-39
- Anahtar Kelimeler: Anti-staphylococcal activity, 1H-Benzimidazolesulphonamide, Methicillin-resistant Staphylococcus aureus, Tautomerism, ANTIMICROBIAL ACTIVITY, INHIBITORS
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
A series of N-substituted-1H-benzimidazole-5(6)-sulfonamides and 3-(5,6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (μg/mL) values. The most active compounds 30, 31, and 32 have the lowest MIC values with 0.39 to 0.19 μg/mL. Among the compounds having sulfonamido moities, 16, 23, and 24 exhibited the strongest antibacterial activity with 1.56 μg/mL MIC values. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.