Electrochemical behavior of indole-3-carboxaldehyde izonicotinoyl hydrazones: Discussion on possible biological behavior


Shirinzadeh H., OZANSOY A., GÜMÜŞTAŞ M., SÜZEN S., ÖZDEN M. S. , ÖZKAN S. A.

Combinatorial Chemistry and High Throughput Screening, vol.13, no.7, pp.619-627, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 7
  • Publication Date: 2010
  • Doi Number: 10.2174/1386207311004070619
  • Title of Journal : Combinatorial Chemistry and High Throughput Screening
  • Page Numbers: pp.619-627
  • Keywords: Indole, hydrazide, hydrazone, electrochemistry, voltammetry, HYDRAZIDE/HYDRAZONE DERIVATIVES, VOLTAMMETRIC DETERMINATION, INDOLE-DERIVATIVES, HUMAN SERUM, PHARMACEUTICALS, ELECTRODES

Abstract

Electrochemical techniques provide valuable information about drug molecules and their mechanisms in the body such as metabolism, which is one of the important actions in drug discovery. Since, many physiological processes depend on oxido-reduction reactions, it is not difficult to find associations between electrochemical and biological reactions regarding electron transfers. To investigate this proposal two compounds namely 1-methylindole-3- carboxaldehyde izonicotinoyl hydrazone and 5-chloro-1H-indole-3-carboxaldehyde izonicotinoyl hydrazone were synthesized, characterized and examined electrochemically using different voltammetric techniques in order to evaluate the possible biological behavior. The characteristics of the corresponding electrode reaction were discussed. A linear response was obtained in the different media for the compounds with low detection limits of the synthesized compounds. © 2010 Bentham Science Publishers Ltd.