Ten cases of neurobrucellosis treated with a combination of ceftriaxone, rifampicin and doxycycline were assessed, Six patients were diagnosed as meningitis, two as myelitis, one as meningoencephalitis and one as polyradiculoneuritis. They were treated with ceftriaxone added to a rifampicin and doxycycline combination, for a period of 2-3 weeks. Rifampicin and doxycycline combination was continued for a period of 8-24 weeks, based on the improvement in clinical findings and CSF abnormality. Fever lasted between 3 and 12 days (7 out of 10 patients had fever on admission). CSF cyto-chemical parameters were back to normal within 2 to 5 months.