© 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.In the course of our program to search for bioactive compounds from the marine sources, the methanol extracts of 8 marine sponges were screened for their antimicrobial activity. Sponges were extracted with methanol and solved in dimethylsulphoxide (DMSO) at a final concentration of 512 µg mL-1 for preparing stock solutions. Antibacterial and antifungal activity tests were carried out against standard and clinical isolates with microdilution method as described in CLSI standards. The extracts of sponge species collected from coasts of Turkey have been shown to possess antibacterial and/or antifungal activity.