Cholinesterase Inhibitory Activity of Some Semi-rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site

Ben Hadda T., Talhi O., Silva A. S. M., ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., Rauf A., ...More

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.18, no.8, pp.711-716, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 18 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.2174/1389557517666170713114039
  • Journal Name: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.711-716
  • Keywords: Alzheimer's disease (AD), cholinesterases, crystalline structure, Petra/Osiris/Molinspiration (POM) analyses, spiro heterocycles, pharmacophore, BIOACTIVITY, ANTIBACTERIAL
  • Lokman Hekim University Affiliated: No

Abstract

Background: Cholinesterase family consists of two sister enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which hydrolyze acetylcholine. Since deficit of acetylcholine has been evidenced in patients of Alzheimer's disease (AD), cholinesterase inhibitors are currently the most prescribed drugs for the treatment of AD.