Ketamine gargle for attenuating postoperative sore throat

CANBAY Ö., ÇELEBİ N., ŞAHİN A. U., Celiker V., Ozgen S., AYPAR Ü.

British Journal of Anaesthesia, vol.100, no.4, pp.490-493, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 100 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1093/bja/aen023
  • Journal Name: British Journal of Anaesthesia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.490-493
  • Keywords: Analgesic techniques, topical, Complications, intubation tracheal, Complications, sore throat, Pharmacology, ketamine
  • Lokman Hekim University Affiliated: Yes


Background. Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21-65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Methods. Forty-six, ASA I-II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). Results. POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05). Conclusions. Ketamine gargle significantly reduced the incidence and severity of POST. © The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved.