Ketamine gargle for attenuating postoperative sore throat
British Journal of Anaesthesia, cilt.100, sa.4, ss.490-493, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 100 Sayı: 4
- Basım Tarihi: 2008
- Doi Numarası: 10.1093/bja/aen023
- Dergi Adı: British Journal of Anaesthesia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.490-493
- Anahtar Kelimeler: Analgesic techniques, topical, Complications, intubation tracheal, Complications, sore throat, Pharmacology, ketamine
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Background. Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21-65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Methods. Forty-six, ASA I-II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). Results. POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05). Conclusions. Ketamine gargle significantly reduced the incidence and severity of POST. © The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved.