Protection of farm goats by combinations of recombinant peptides and formalin inactivated spores from a lethal Bacillus anthracis challenge under field conditions

Koehler, Susanne; Buyuk, Fatih; Celebi, Ozgur; Demiraslan, Hayati; DOĞANAY, MEHMET; Sahin, Mitat; Moehring, Jens; Ndumnego, Okechukwu; Otlu, Salih; van Heerden, Henriette; Beyer, Wolfgang

doi:10.1186/s12917-017-1140-2

Protection of farm goats by combinations of recombinant peptides and formalin inactivated spores from a lethal Bacillus anthracis challenge under field conditions

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Koehler S. M., Buyuk F., Celebi O., Demiraslan H., DOĞANAY M., Sahin M., ...More

BMC VETERINARY RESEARCH, vol.13, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 13
Publication Date: 2017
Doi Number: 10.1186/s12917-017-1140-2
Journal Name: BMC VETERINARY RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Bacillus anthracis, Anthrax, Vaccination, Animal vaccine, COMPARATIVE EFFICACY, SUBOPTIMAL AMOUNTS, GUINEA-PIGS, VACCINE, ANTIGEN, MICE, IMMUNIZATION, PROTEIN, STRAINS, TOXIN
Lokman Hekim University Affiliated: No

Abstract

Background: Bacillus (B.) anthracis, the causal agent of anthrax, is effectively controlled by the Sterne live spore vaccine (34F2) in animals. However, live spore vaccines are not suitable for simultaneous vaccination and antibiotic treatment of animals being at risk of infection in an outbreak situation. Non-living vaccines could close this gap.