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Ondokuz Mayis Universitesi Tip Dergisi, vol.17, no.1, pp.17-24, 2000 (Scopus)
Glucose utilization may impair during stress such as surgery. Fructose solution may be an alternative to glucose solution during surgery. The aim of this study is to evaluate acute metabolic effects of fructose and glucose infusions under isofluorane and halothane anaesthesia. Sixty ASA (American Society of Anesthesiologists Physical Status Classification) I-II patients undergoing elective surgery were selected. The patients were divided into two groups: isofluorane (group I) or halothane (group II). Isofluorane and halothane groups were further divided into two more subgroups: a. Fructose infusion, b. Dextrose(glucose) infusion group. Basal blood samples were drawn before the administration of 5% dextrose or fructose infusions. Maintenance of anaesthesia were isofluorane (1%) in O2-N2O (67.7-33.3%) and halothane (0.6%) in O2-N2O (67.7-33.3%) in groups I and II, respectively. Serum glucose, lactic acid (LA), piruvic acid (PA), bicarbonate, sodium, potassium, chloride, creatinine and blood urea nitrogen (BUN) levels were measured before the anaesthesia and at 30th and 60th minutes after the beginning of anaesthesia. Serum glucose levels were increased significantly in both groups, but the increament was more marked in the patients who recieved dextrose solution. Serum LA and PA levels increased and bicarbonate levels decreased significantly in the patients who recieved fructose solution. These results suggest that fructose solution may be an alternative carbohydrate to glucose solution, but it must be used cautiously in patients at the risk of lactic acidosis.