Impairment of vestibulo-collic reflex and linear vestibulo-ocular reflex in pediatric-onset multiple sclerosis patients

ERTUĞRUL G., AKSOY S., Konuskan B., Eskandarian L., Oguz K. K., Anlar B.

Clinical Neurophysiology, cilt.132, sa.8, ss.1813-1819, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 132 Sayı: 8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.clinph.2021.04.014
  • Dergi Adı: Clinical Neurophysiology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1813-1819
  • Anahtar Kelimeler: Multiple sclerosis, Pediatric, Vestibular evoked myogenic potentials, Reflex, EVOKED MYOGENIC POTENTIALS, BRAIN-STEM INVOLVEMENT, MRI
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2021 International Federation of Clinical NeurophysiologyObjectives: This study aimed to examine the vestibulo-collic reflex (VCR) and linear vestibulo-ocular reflex (lVOR) and their correlation with brain lesions in pediatric-onset multiple sclerosis (POMS). Methods: The study group consisted of 17 patients (34 ears) with POMS (mean age 18.73 ± 2.02, mean age at disease onset 14.64 ± 1.36 years), and the control group included 11 age-matched healthy subjects (22 ears). Ocular and cervical Vestibular Evoked Myogenic Potentials (oVEMP and cVEMP) were performed to assess IVOR and VCR pathways. Magnetic Resonance Imaging was evaluated in the study group. Results: In the POMS group, 47.05 % of oVEMPs and 17.64 % of the cVEMPs were abnormal, while all VEMPs were normal in the control group. The oVEMP amplitude was associated with infratentorial lesion volume (r = −0.459, p = 0.01) and total lesion volume of the brainstem and cerebellum (r = −0.450, p = 0.01). The cVEMP asymmetry ratio was correlated with the deep white matter lesion volume (r = 0.683, p < 0.001). The MVEMP scores were found to correlate only with lesion volumes in the cerebellum (r = 0.488, p = 0.04) and infratentorial region (r = 0.573, p = 0.01). Conclusions: Ocular and cervical VEMP abnormalities confirm that lVOR and VCR pathways may be affected in early POMS. Significance: Routine use of the VEMP test, especially the oVEMP test is recommended as a useful tool in the follow-up of POMS patients.