The role of cytopathology in diagnosing HPV induced oropharyngeal lesions


Mehrotra R., Sharma N., UMUDUM H., CEYHAN K., Rezanko T.

Diagnostic Cytopathology, vol.40, no.9, pp.839-843, 2012 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 40 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1002/dc.21756
  • Journal Name: Diagnostic Cytopathology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.839-843
  • Keywords: oral cytology, human papilloma virus, p16, in situ hybridization, polymerase chain reaction, SQUAMOUS-CELL-CARCINOMA, IN-SITU HYBRIDIZATION, POLYMERASE CHAIN-REACTION, HUMAN-PAPILLOMAVIRUS DNA, FINE-NEEDLE-ASPIRATION, MALIGNANT LESIONS, HEAD, CANCER, PREVALENCE, SURVIVAL

Abstract

HPV detection in fine needle aspirates from suspected head and neck metastasis may be useful in clinching the diagnosis of HPV related oral squamous cell carcinoma. Ascertaining the HPV status of a particular tumor on cytological specimens could be useful for prognostication as HPV-related tumors appear to have a better prognosis and clinical outcome. The various techniques of detection are reviewed. © 2011 Wiley Periodicals, Inc.