Copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligand

DOĞAN Ö., BULUT A., Polat S., Ali Tecimer M.

Tetrahedron Asymmetry, vol.22, no.16-17, pp.1601-1604, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 16-17
  • Publication Date: 2011
  • Doi Number: 10.1016/j.tetasy.2011.09.003
  • Journal Name: Tetrahedron Asymmetry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1601-1604
  • Lokman Hekim University Affiliated: No

Abstract

A series of chiral phosphine PFAM and phosphine oxide POFAM ligands were studied for the copper-catalyzed asymmetric diethylzinc addition to enones. One of these ligands, PFAM2, was an efficient catalyst with a variety of enones to give conjugate addition products in up to 96% yield and 92% ee. Copyright © 2011 Published by Elsevier Ltd. All rights reserved.