Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.25, sa.4, ss.471-477, 2005 (Scopus)
Objective: In this study involving patients with cholesterol/high density lipoprotein (HDL) cholesterol ratios > 5.6, which is an atherogenic risk index for coronary artery disease (CAD), the effects of diet and simvastatin treatment on serum lipid profile and HDL cholesterol sub-fractions were investigated. Material and Methods: Total cholesterol, triglyceride, low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C), high-density lipoprotein (HDL-C), HDL2-C, HDL3-C and cholesterol/HDL ratios were evaluated in 40 patients with cholesterol/HDL cholesterol ratios > 5.6. Results: After diet and diet + simvastatin therapy, total cholesterol levels were decreased by 1% (p> 0.05) and LDL-C levels were increased by 4% (p> 0.05) in the diet group, whereas both total cholesterol and LDL-C levels were significantly decreased in the diet + simvastatin group, 5% and 20%, respectively (p< 0.05 and p< 0.05). In the diet group, HDL-C and HDL 3-C levels were increased by 5% and 23%, respectively (p>0.05 and p= 0.002), and HDL2-C levels were decreased by 11% (p= 0.019). In the diet + simvastatin group, significant increases in HDL-C (11%; p= 0.0002), HDL2-C (40%; p= 0.0003) and HDL3-C (5%; p= 0.036) were determined. Conclusion: The therapeutic approach (i.e. diet + simvastatin) appears to be more effective than dietary treatment alone for the prevention of atherogenesis and regression of hyperlipidemia. Copyright © 2005 by Türkiye Klinikleri.