Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.35, sa.4, ss.227-234, 2007 (Scopus)
Aim: Lornoxicam generates a more significant anti-hiperalgesic effect than piroxicam and meloxicam. Our aim is to investigate the additive effects of lornoxicam and ketamine on nociceptive threshold of rat hindpaw and anti-inflammatory effect, with hyperalgesia and inflammation models, respectively. Materials and methods: This double blinded, randomized, placebo controlled trial includes 122 male Wistar albino rats. The hyperalgesic and inflammatory steps were made at 6 distinct groups. Group L received lornoxicam (1.3 mg kg -1, n=20), Group K ketamine (10 mg kg -1, n=20), Group KL ketamine (10 mg kg -1) and lornoxicam (1.3 mg kg -1) (n=23), Group Ç solvent (n=19), Group S saline (n=20) and Group ÇS received solvent and saline (n=20) at equal volumes, intraperitoneally. For hyperalgesic and inflammatory steps, all drugs were given intraperitoneally before15 minutes and 30 minutes, respectively, before carregeenan injection to hindpaw. 3 hours after intraplantar caregeenan injection, caregeenan induced hindpaw edema was measured via pletysmometer. 30, 60, 90, 120 minutes after formaline injection, the time for withdrawal of the hindpaw was measured by using plantar test. Results: In Group L (7.75±3.23), Group K (10.3±4.14) and Group KL (7.29±3.57), hindpaw edema measurements were found to be significantly less than in Group Ç (17.9±4.79), Group S (17.96±5.73) and Group ÇS (14.08±3.79). Anti-hyperalgesic effect was not found to be different between the Groups I, II and III, but these groups were found to have more anti-hyperalgesic effect than Group V (p<0.02). Conclusion: Lornoxicam and ketamine have no additive effect on inflammation and hyperalgesia.