Akademik Veri Yönetim Sistemi
Turkish Journal of Biochemistry, cilt.37, sa.4, ss.471-477, 2012 (SCI-Expanded)
Objective: Glomerular filtration rate calculation values have been established for the evaluation of renal function in the last decade. Glomerular filtration rate calculation was done by creatininebased equations as simple Modification of Diet in Renal Disease (MDRD), extended- Modification of Diet in Renal Disease (Ex-MDRD), Cockcroft and Gault (CG) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). In this study, we aimed to show the limits of the difference and correlations in the values of glomerular filtration rate formulas based serum creatinine measurements by using the measurement of creatinine autoanalyzers belonging to four different companies, using the Jaffe reaction. Methods: Serum samples of forty five patients, who had been admitted to Ankara Numune Education and Research Hospital samples were analysed for serum creatinine with Jaffe method on five different analyzers. Glomerular filtration rate calculation was done with BMDRD, Ex- MDRD, CG and CKD-EPI and compared statistically. Paired Student's T test was done to detect the differences between the analyzers for each glomerular filtration rate. Also, Pearson's correlation analysis was used for evaluation of correlation between different analyzers and formulas. Results: Glomerular filtration rates calculated with CG formula in all analyzers and with CKDEPI formula in most of the analyzers were statistically compatible with each other (p<0.05). Conclusion: Differences between the calculation of glomerular filtration rate is caused by differences in creatinine measurement. However, this difference in our study for glomerular filtration rate values calculated by the CG and CKD-EPI formulas were not significant as the other formula based glomerular filtration rate calculations were. For this reason, we concluded that patients can be followed in different treatment centers more healthy with widespread reporting of glomerular filtration rate values calculated with CG and CKD-EPI formulas. © TurkJBiochem.com.