Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.20, sa.3, ss.169-171, 1992 (Scopus)
This study was designed to investigate the effects of propofol which is known to contain soya bean oil and egg phosphatides, on serum triglycerides, cholesterol and cholesterol esters. 20 ASA I-II patients scheduled to undergo various elective operations were included. The patients received diazepam 10 mg orally the night before the operation, meperidine 1 mg/kg and atropine 0.5 mg IM. 60 minutes prior to induction for premedication. Anesthesia was induced with propofol 2-2.5 mg/kg and succinylcholine 1.5 mg/kg and maintained by propofol infusion 6-12 mg/kg/h, supplemented with N2O and O2 (3/3 l/min). Succinylcholine was added in doses of 1 mg/kg when needed. Blood samples were obtained prior to induction as control values and 30 minutes after the infusion ended to determine serum triglycerides, cholesterol, HDL-chol, VLDL-chol and LDL-chol levels. Although there was no statistically significant difference in triglyceride, cholesterol, HDL-chol and VLDL-chol levels when compared to control values (p ~ 0.05). Decrease in LDL-chol levels were statistically significant (p _ 0.05). In conclusion, propofol, is a preferable anesthetic agent in patients with atherosclerosis.