Hypersensitivity reactions to biologicals: An EAACI position paper

BAVBEK S., Pagani M., Alvarez-Cuesta E., Castells M., Dursun A. B., Hamadi S., ...Daha Fazla

ALLERGY, cilt.77, sa.1, ss.39-54, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/all.14984
  • Dergi Adı: ALLERGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.39-54
  • Anahtar Kelimeler: biologicals, desensitization, drug hypersensitivity, hypersensitivity reactions, monoclonal Abs, RAPID SUBCUTANEOUS DESENSITIZATION, ADVERSE-REACTIONS, INFUSION REACTIONS, IGE ANTIBODIES, RITUXIMAB HYPERSENSITIVITY, SKIN-TESTS, IN-VITRO, ALLERGY, MANAGEMENT, CHEMOTHERAPY
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Biologicals are crucial targeted therapeutic agents in oncological, immunological, and inflammatory diseases, and their use in clinical practice is broadening. In recent years, the spread of Personalized Precision Medicine has facilitated a proliferation of new treatment options, especially biologicals. Consequently, biologicals are now among the drugs that most frequently cause hypersensitivity reactions (HSRs). Patients can develop HSRs to these agents during the first-lifetime exposure or after repeated exposure, and these HSRs can be potentially life-threatening or limit therapeutic options. Despite the relatively high prevalence, the underlying mechanisms of these HSRs remain obscure, and the optimal management pathways are still a matter of discussion. In this Position Paper, the authors will provide evidence-based recommendations for diagnosing and managing HSRs to biologicals. Additionally, the document defines unmet needs as an opportunity to shape future research.