Cyclosporine-A induced neurotoxicity after renal transplantation

DERİCİ Ü., Arinsoy T., Sindel S., TALI E. T., Leventoglu A., Sert S.

Acta Neurologica Belgica, cilt.101, sa.2, ss.124-127, 2001 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 2
  • Basım Tarihi: 2001
  • Dergi Adı: Acta Neurologica Belgica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.124-127
  • Anahtar Kelimeler: renal transplantation, cyclosporine A, neurotoxicity, MRI, HEART-TRANSPLANTATION, LIVER-TRANSPLANTATION, BLINDNESS
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Cyclosporine-A is a highly potent immunosuppressive agent for solid organ transplantation, but has many side effects including nephrotoxicity, hypertension, gum hyperplasia, hepatotoxicity, and neurotoxicity. Neurotoxicity is a less known toxic effect. The pathogenesis of this effect is unclear. However, it has been postulated that hypomagnesemia, hypocholesterolemia, corticosteroids, and/or neurotoxic substances can induce this syndrome. Also, it has been suggested that the endothelial damage caused by Cyclosporine-A may contribute to neuropeptide-mediated ischemia in the brain and lead to the development of neurological symptoms. In this report, we present a case with reversible neurologic deficits whose symptoms returned to normal after the cessation of cyclosporine-A.