The preemptive analgesia for ambulatory hand surgery: A randomized controlled pilot study to compare tramadol, rofecoxib and lornoxicam Günübirlik El Cerrahisi Vakalarinda Preemptif Analjezi: Tramadol, Rofekoksib ve Lornoksikam'in Karşilaştirildiǧi Randomize, Kontrollü Çalişma


Anestezi Dergisi, vol.13, no.2, pp.116-120, 2005 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2005
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.116-120
  • Keywords: Ambulatory hand surgery, Preemptive analgesia, Rofecoxib and lornoxicam, Tramadol
  • Lokman Hekim University Affiliated: Yes


The preemptive administration of NSAID's and opioid-containing oral analgesics may reduce postoperative analgesic requirements and hypersensitivity. We studied the preemptive analgesic efficacy of three drugs in 40 ASA I-III patients (mean age: 46 (16-70), male:female= 1:3) scheduled to undergo ambulatory hand surgery with median nerve blockade. 30 minutes before surgery, oral analgesic tablets were given as follows: tramadol 100 mg, rofecoxib 50 mg, lornoxicam 8 mg and 675 mg Vitamin-C. Follow-up medication consisted of oral paracetamol 500 mg on demand. Analgesic efficacy was evaluated using a visual analogue scale at five different time intervals during the 24-hour postoperative study period. Global pain relief on a 5-grade scale, the total number of analgesic tablets, the frequency and severity of adverse effects were recorded. The study drugs were not statistically different from each other for preemptive analgesic effects. In three of the groups, excluding Group L, the variation of VAS in the postoperative period was statistically significant. The 6th hour records were statistically significant for Group L when compared to Group P (p=0.023), but not when compared to Groups R and T. Oral lornoxicam, tramadol and rofecoxib administered 30 minutes before surgery provide effective postoperative analgesia for ambulatory hand surgery.