Akademik Veri Yönetim Sistemi
Journal of Agriculture and Food Research, cilt.29, 2026 (ESCI, Scopus)
The prevalence of heart failure (HF) has significantly increased worldwide, highlighting the urgent need for cardioprotective interventions. Since increased oxidative stress plays a significant role in the development of HF, we aimed to evaluate effects of a nutrient-supplement pine bark extract, a vegetable-capsule formula enhanced synergistically with rose hips and vitamin C (PBE), in animals subjected to isoproterenol (ISO)-induced HF to determine whether it has protective, preventive, or both types of effects. It was induced in mice by ISO-injection, while PBE was administered before or after ISO-injection (Pre-group or Post-group) for 4-week. The PBE-supplementation significantly attenuated oxidative stress as systemic and organ levels. The elevated oxidative stress markers in ISO-treated animals, including total oxidant status, malondialdehyde, 4-hydroxy-2-nonenal, 8-hydroxy-2′-deoxyguanosine, along with decreased total antioxidant status and arylesterase activity in the heart and liver, were significantly reversed by both Pre- or Post-PBE administration. Furthermore, the heart rate and prolonged QRS-duration and QT-interval observed in ECG-recordings of the ISO-group were significantly normalized by PBE-supplementation, in parallel with structural heart-tissue repair, including attenuations in collagen fiber accumulation and extracellular matrix remodeling. Importantly, a marker of ventricular repolarization heterogeneity, prolonged Tpeak-Tend (Tp-e) interval, was also significantly restored by PBE administrations. Overall, our data demonstrate an unbalanced redox status in the heart contributes to increased cardiac electrical instability and dispersion, which can predict arrhythmic risk in the ISO-group. These adverse effects in the heart were profoundly improved by attenuation of oxidative stress and redox-homeostasis restoration through both types of PBE-administration, with more effective in the Pre-treatment.