Factors influencing pregnancy rates in intrauterine insemination cycles


GÜVEN S., Gunalp G. S., Tekin Y.

Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol.53, no.4, pp.257-265, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 4
  • Publication Date: 2008
  • Journal Name: Journal of Reproductive Medicine for the Obstetrician and Gynecologist
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.257-265
  • Keywords: Assisted reproductive techniques, Intrauterine insemination, Pregnancy
  • Lokman Hekim University Affiliated: No

Abstract

OBJECTIVE: To identify the predictors of pregnancy rate (PR) among women undergoing intrauterine insemination (IUI) cycles. STUDY DESIGN: Two hundred thirty-two women undergoing 255 IUI cycles were retrospectively evaluated according to clinical and semen characteristics in terms of PRs. RESULTS: The overall PR was 9.4%. The PR was 7.9% in the primary infertility group, whereas the rate was 21.4% in the secondary in fertility group (p < 0.05). The pregnancy rate was 3.1% for 1 preovulatory follicle, 9.3% for 2 follicles, 16.9% for 3 and 23.1% for 4 (p < 0.05). The PR increased in accordance with the total motile sperm count before sperm preparation (p > 0.05); however, the PR was significantly higher in sperm morphology of > 4% (according to Kruger criteria) than in the ≤ 4% group (6.7% vs. 22.2%, respectively; p = 0.003). Using binary logistic regression analysis, the number of preovulatory follicles and the percentage of normal sperm morphology in processed sperm had the maximum power to predict the PR following IUI. CONCLUSION: Other than clinical and laboratory characteristics, only the number of preovulatory follicles and the percentage of normal sperm morphology in pro cessed sperm can be used in the prediction of a favorable IUI outcome. © Journal of Reproductive Medicine®, Inc.