Lengthening of QT Interval Caused by Fluconazole in a Newborn
Journal of Clinical Toxicology, vol.2, no.5, pp.1-3, 2012 (Peer-Reviewed Journal)
- Publication Type: Article / Case Report
- Volume: 2 Issue: 5
- Publication Date: 2012
- Doi Number: 10.4172/2161-0495.1000132
- Journal Name: Journal of Clinical Toxicology
- Journal Indexes: EBSCO Education Source
- Page Numbers: pp.1-3
- Lokman Hekim University Affiliated: No
Abstract
Fluconazole is a broadly used drug, especially in critically ill newborns hospitalized in neonatal intensive care
units. The drug is safe and effective in both prophylaxis and treatment of fungal infections in newborns. In children,
the most common side effects of fluconazole are associated with the gastrointestinal tract or skin. It can induce
QT prolongation, which may lead to torsade de pointes and sudden death in adults, although rarely. We present
lengthening of the QT interval in a newborn treated with fluconazole. To our knowledge, this is the first case of QT
prolongation caused by fluconazole in this age group