Drug Design of Inhibitors of Alzheimer's Disease (AD): POM and DFT Analyses of Cholinesterase Inhibitory Activity of beta-amino di-Carbonyl Derivatives

Ben Hadda, Taibi; Rauf, Abdur; Zgou, Hsaine; ŞENOL DENİZ, FATMA; ERDOĞAN ORHAN, İLKAY; Mabkhot, Yahia; Althagafi, Ismail; Farghaly, Thoraya; Alterary, Seham

doi:10.2174/1389557518666181102102816

Drug Design of Inhibitors of Alzheimer's Disease (AD): POM and DFT Analyses of Cholinesterase Inhibitory Activity of beta-amino di-Carbonyl Derivatives

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Ben Hadda T., Rauf A., Zgou H., ŞENOL DENİZ F. S., ERDOĞAN ORHAN İ., Mabkhot Y. N., ...More

MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol.19, no.8, pp.688-705, 2019 (SCI-Expanded)

Publication Type: Article / Review
Volume: 19 Issue: 8
Publication Date: 2019
Doi Number: 10.2174/1389557518666181102102816
Journal Name: MINI-REVIEWS IN MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.688-705
Keywords: beta-Amino dicarbonyl, cholinesterase inhibition, Alzheimer's disease (AD), DFT calculations, Petra/Osiris/Molinspiration (POM) analysis, in vitro, EXPERIMENTAL-VERIFICATION, ANTIOXIDANT ACTIVITIES, SCHIFF-BASES, ANTIBACTERIAL, IDENTIFICATION, BIOACTIVITY, COMPLEXES
Lokman Hekim University Affiliated: No

Abstract

Background: Since deficit of acetylcholine has been evidenced in the Alzheimer's disease (AD) patients, cholinesterase inhibitors are currently the most specified drug category for the remediation of AD.