Serum lipid-bound sialic acid concentrations in patients with breast cancer at different clinical stages
Gazi Medical Journal, cilt.13, sa.3, ss.133-137, 2002 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 3
- Basım Tarihi: 2002
- Dergi Adı: Gazi Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.133-137
- Anahtar Kelimeler: Breast Cancer, Sialic Acid
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Purpose: Sialic acid in serum has been proposed as a useful cancer marker and periodical determinations of sialic acid in patients with tumor might be a reliable marker of tumor progression. The aim of this study was to investigate whether lipid-bound sialic acid can be used as a tumor marker for distinguishing patients with breast cancer from healthy individuals. Methods: Serum lipid-bound sialic acid levels were determined in 11 breast cancer patients who have just been diagnosed and not yet operated on 12 breast cancer patients who had been operated within 1 month, 9 patients in remission and 9 healthy female individuals. Lipid bound sialic acid was determined by the method of Katopodis and Stock. Results: All groups of patients except patients in remission showed mean values of lipid-bound sialic acid levels higher than healthy controls (p < 0,05). Conclusion: Our results indicate that serum lipid-bound sialic acid levels may be useful when used with other tumor markers for distinguishing patients with breast cancer from healthy subjects.