Akademik Veri Yönetim Sistemi
Gazi Medical Journal, cilt.13, sa.3, ss.133-137, 2002 (Scopus)
Purpose: Sialic acid in serum has been proposed as a useful cancer marker and periodical determinations of sialic acid in patients with tumor might be a reliable marker of tumor progression. The aim of this study was to investigate whether lipid-bound sialic acid can be used as a tumor marker for distinguishing patients with breast cancer from healthy individuals. Methods: Serum lipid-bound sialic acid levels were determined in 11 breast cancer patients who have just been diagnosed and not yet operated on 12 breast cancer patients who had been operated within 1 month, 9 patients in remission and 9 healthy female individuals. Lipid bound sialic acid was determined by the method of Katopodis and Stock. Results: All groups of patients except patients in remission showed mean values of lipid-bound sialic acid levels higher than healthy controls (p < 0,05). Conclusion: Our results indicate that serum lipid-bound sialic acid levels may be useful when used with other tumor markers for distinguishing patients with breast cancer from healthy subjects.