Prognosis in anticoagulan therapy related intracerebral hemorrhage Anti̇koagülan kullanimina baǧli geli̇şen i̇ntraserebral hemoraji̇lerde prognoz


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Eruyar E., Gun̈ey F.

Turk Beyin Damar Hastaliklar Dergisi, vol.17, no.3, pp.101-104, 2011 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.5505/tbdhd.2011.14633
  • Journal Name: Turk Beyin Damar Hastaliklar Dergisi
  • Journal Indexes: Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.101-104
  • Keywords: Intracerebral hemorrhage, Mortality, Warfarin
  • Lokman Hekim University Affiliated: No

Abstract

PURPOSE: Warfarin therapy is frequently used to prevent thromboembolic complications. Warfarin-related intracranial hemorrhage is uncommon and it has high mortality rate. In this article, we presented the clinical features of literature because of the Warfarin-related intracranial haemorrhage is uncommon and highly mortal. MATERIAL AND METHODS: In this study, 18 patients included the study among the patients who admitted to our clinic with intracerebral hemorrhage due to warfarin between 2006 and 2011. The further investigations were performed in patients with suspected of bleeding not result from warfarin to rule out the secondary bleeding causes and patients with secondary causes (hematologic disease etc.) did not include the study. Comorbid diseases, indications for initiation of warfarin, arrival blood pressure, INR values and GCS values of patients were registered. The location of hemorrhage identified with taken computed tomography scan in all patients. We have identified the causes which affect the morbidity and mortality and compared their effects on prognosis. RESULTS: Eight (44.4%) were man and 10 (55.6%) were woman of these patients. The mean age was 67 years (range, 27-108). Eight patients (44.4%) for atrial fibrillation, 5 patients (27.8%) for mechanical heart valve, 3 patients (16.7%) for pulmonary embolism or deep vein thrombosis and 2 patients (11.1%) for other cardiac causes had been received OAC. The mean arrival INR value of patients was 7.8 (1.58-39.4). The mean age was 73 for patients who died and 63 for survived 12 patients. The mean arrival INR level was 11.1 for 6 patients who died and 2 of them (33%) had normal INR level. The mean arrival INR level was 6.1 and 6 of them (50%) had normal INR level. The mean GCS score was 8 for patients who died and 13 for survived patients. CONCLUSION: The present study have shown that OAC usage especially during advanced age, higher INR level, lower arrival GCS score and hemorrhage which extended to ventricle have effects on mortality. These results support the earlier studies. These results should be supported by the future studies on larger populations.