Assessment of In Vitro Antigenotoxic Effect of Nigella Sativa Oil

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Zor M., Aslan E. L.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.1, pp.115-118, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2020.09471
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.115-118
  • Keywords: Cyclophosphamide, Nigella saliva oil, micronucleus, genotoxicity, MICRONUCLEUS ASSAY, ETHANOLIC EXTRACT, GENOTOXICITY, LYMPHOCYTES, HEPATOTOXICITY, THYMOQUINONE, FREQUENCY, TOXICITY, DAMAGE
  • Lokman Hekim University Affiliated: Yes

Abstract

Objectives: Cyclophosphamide (CP) is an alkylating agent widely used as an antineoplastic and immunosuppressive agent. The genotoxicity of CP has been studied in a variety of in vivo and in vitro systems and is routinely used as a positive control in genotoxicity tests. Traditional medicine Nigella sativa L., (N. sativa), Ranunculaceae family, especially in the Eastern Mediterranean countries, especially in many countries, and is widely used in many countries as a spice and folk medicine since the time of Dioscorides used as a plant. In this study, it was aimed to show the protective effects of N. sativa oil at different concentrations against the genotoxic effects of CP by micronucleus test.