Assessment of In Vitro Antigenotoxic Effect of Nigella Sativa Oil

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Zor M., Aslan E. L.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.1, ss.115-118, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2020.09471
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.115-118
  • Anahtar Kelimeler: Cyclophosphamide, Nigella saliva oil, micronucleus, genotoxicity, MICRONUCLEUS ASSAY, ETHANOLIC EXTRACT, GENOTOXICITY, LYMPHOCYTES, HEPATOTOXICITY, THYMOQUINONE, FREQUENCY, TOXICITY, DAMAGE
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Objectives: Cyclophosphamide (CP) is an alkylating agent widely used as an antineoplastic and immunosuppressive agent. The genotoxicity of CP has been studied in a variety of in vivo and in vitro systems and is routinely used as a positive control in genotoxicity tests. Traditional medicine Nigella sativa L., (N. sativa), Ranunculaceae family, especially in the Eastern Mediterranean countries, especially in many countries, and is widely used in many countries as a spice and folk medicine since the time of Dioscorides used as a plant. In this study, it was aimed to show the protective effects of N. sativa oil at different concentrations against the genotoxic effects of CP by micronucleus test.