Effect of chronic stress and L-carnitine on rat stomach


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Izgüt-Uysal V. N., BÜLBÜL M., Tan R., DERİN N., ÜSTÜNEL İ., Aǧar A., ...More

Journal of Physiological Sciences, vol.57, no.3, pp.187-192, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.2170/physiolsci.rp004707
  • Journal Name: Journal of Physiological Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.187-192
  • Keywords: restraint stress, L-carnitine, lipid peroxidation, gastric injury, REPEATED RESTRAINT STRESS, GASTRIC-MUCOSAL INJURY, RED-CELL LIPIDS, OXIDATIVE DAMAGE, SENSORY NERVES, AUTOXIDATION, PEROXIDATION, DERIVATIVES, PROTECTION, BRAIN
  • Lokman Hekim University Affiliated: No

Abstract

Background and Aim: L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury. Methods: Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E2 and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated. Results: Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E2 and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E2, and mucus content in gastric mucosa, but it increased catalase activity. Conclusions: L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.