The effect of Sumatriptan in ischemic conditions in the rat heart Sumatriptanın Sıçan kalbinde iskemik koşullardaki etkisi


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Altunkaynak-çamca H. Ö. , Tecder-ünal M., Tuncer M.

Turkish Journal of Pharmaceutical Sciences, vol.15, no.3, pp.328-332, 2018 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.4274/tjps.03371
  • Journal Name: Turkish Journal of Pharmaceutical Sciences
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.328-332
  • Keywords: Sumatriptan, heart, ischemia and reperfusion, ischemic preconditioning, arrhythmia, INDUCED ARRHYTHMIAS, CORONARY-ARTERY, ISCHEMIA, RECEPTORS, AGONIST, 5-HYDROXYTRYPTAMINE, PHARMACOLOGY, CONTRACTIONS, METABOLISM, ELETRIPTAN
  • Lokman Hekim University Affiliated: No

Abstract

© Turk J Pharm Sci, Published by Galenos Publishing House.Objectives: The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection. Materials and Methods: The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure and heart rate were recorded to calculate PRP. Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters. Results: The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p<0.05). The incidence of VT in the IPC, SUM-IR, and SUM-IPC groups was significantly lower than in the IR group (p<0.05). VF was only observed in the IR group. Conclusion: SUM protects the heart against IR injury but is not as protective as IPC alone. Although SUM diminishes IPC-induced protection against VT, the preventive effect of SUM against VF may be predictive for cardioprotection in ischemic conditions.