Is there a relationship between small, dense LDL and lipoprotein -associated phospholipase A2 mass in dialysis patients?

Sönmez D., Fidan Y., Özcan O., Azak A., Şeneş M., Duranay M., ...More

Clinical Laboratory, vol.60, no.9, pp.1431-1437, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 9
  • Publication Date: 2014
  • Doi Number: 10.7754/clin.lab.2013.130910
  • Journal Name: Clinical Laboratory
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1431-1437
  • Keywords: cardiovascular diseases, end stage renal disease, C-reactive protein, inflammation, lipoprotein-associated phospholipase A(2), low density lipoprotein, ACETYLHYDROLASE ACTIVITIES, CARDIOVASCULAR-DISEASE, HEMODIALYSIS, ATHEROSCLEROSIS, DYSLIPIDEMIA, MEMBRANES, PROFILES, MARKER, RISK, FLUX
  • Lokman Hekim University Affiliated: No

Abstract

© Copyright.Background: We aimed to measure small, dense LDL (sdLDL) and lipoprotein-associated phospholipase A2 (LpPLA2) concentrations and to evaluate their relationship with other risk factors of atherosclerotic heart disease in dialysis patients.Methods: Study group consisted of 30 peritoneal dialysis and 20 hemodialysis patients with 20 healthy control subjects. sdLDL was measured by homogeneous LDL assay after precipitation of Apo B containing lipoproteins with heparin-magnesium. Lp-PLA2 mass was measured by immunoturbidimetric assay.Results: sdLDL concentrations in the samples collected before hemodialysis and peritoneal dialysis treatment were significantly higher than the control group (p < 0.05). Lp-PLA2 concentrations of both pre-hemodialysis and pentoneal dialysis groups were higher than control group (p < 0.05). There was not a significant correlation between sdLDL and Lp-PLA2. sdLDL concentrations are significantly decreased after a hemodialysis session.Conclusions: sdLDL and Lp-PLA2 concentrations are increased independently in the end stage renal failure patients who are receiving dialysis treatment.