Peripheral T cell receptors αβ, and γδ in patients with Hodgkin's lymphoma

Akan H., Beksac M., Aydogdu I., Koc H., İLHAN ., Ozcan M.

British Journal of Haematology, cilt.87, sa.3, ss.544-547, 1994 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1111/j.1365-2141.1994.tb08310.x
  • Dergi Adı: British Journal of Haematology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.544-547
  • Anahtar Kelimeler: Hodgkin's lymphoma, TCR αβ, TCR γδ
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

Antigen recognition by T cells is determined by an antigen specific T cell receptor (TCR). Two heterodimeric TCR structures associated with CD3 have been defined: TCR αβ and TCR γδ. αβ and its function are well described but the role of TCR γδ in normal and lymphoproliferative disorders is not well established. In newly diagnosed or relapsed/refractory Hodgkin's disease (HD), a disease associated with defective T cell functions and increased sIL-2R, we determined levels of seven TCR αβ variable regions [βV5(a), βV5(b), βV6(a), βV12(a), αβV(a), αV2a)] and TCR γδ by using monoclonal antibodies (MCA). TCR γδ levels did not show any difference, but several variable regions of the TCR αβ differed when groups are compared with each other and the control group.