Journal of Reproductive Medicine, vol.61, no.5, pp.483-488, 2016 (SCI-Expanded)
© Journal of Reproductive Medicine®, Inc.OBJECTIVE: To present our experiences with an innovative surgical approach for vaginal agenesis that uses amnion as the allograft to create a functional neovagina. STUDY DESIGN: This study involved 5 patients with diagnosed vaginal agenesis. One patient had karyotype 46,XY and was diagnosed with complete androgen insensitivity syndrome, whereas the others had karyotype 46,XX and were diagnosed with Mayer-Rokitansky-Küster-Hauser syndrome. All patients underwent McIndoe vaginoplasty using amnion and were followed up at 2 weeks, 3 months, 6 months, and 12 months postsurgery. Functionality of the neovagina was assessed by Rosen Female Sexual Function Index (FSFI) questionnaire. RESULTS: At the 12-month follow-up 1 patient reported an inability to use the vaginal dilator effectively; for the other 4 patients the mean depth of the neovagina was 9.5 cm and the mean width was 3.5 cm. The mean overall FSFI score was 28.3. CONCLUSION: McIndoe vaginoplasty is a simple, safe, and quick operative method that results in a functional vagina. The amnion is a suitable material to apply to the surface of the neovagina because it is readily available and does not have any associated immune rejection problems or costs.