Akademik Veri Yönetim Sistemi
Acta Anaesthesiologica Italica / Anaesthesia and Intensive Care in Italy, cilt.55, sa.1, ss.79-89, 2004 (Scopus)
Objective: The aim of this study was to determine which drug, propofol or midazolam, was more suitable for patient-controlled sedation in septoplasty operations with respect to sedation level, patient and surgeon satisfaction and haemodynamic profile. Design: Prospective randomized controlled clinical study. Setting and patients: Thirty male patients, ASA I-II (20-45 years), undergoing ambulatory septoplasty were recruited. All patients received 1 μg.kg -1 intravenous fentanyl. A patient-controlled analgesia device (Abbott, APM) was used. The loading and bolus doses of propofol and midazolam were 0.7 mg.kg-1/0.25 mg.kg-1 and 0.03 mg.kg -1/5 μg.kg-1, respectively. Lockout intervals were 5 minutes. An additional dose of fentanyl (1 μg.kg-1) was added according to sedation level. Sedation level was assessed at four different times during surgery (1: awake, anxious; 2: awake, not anxious; 3: sedated, speech blurred; 4: eyes closed, responds to verbal stimulus). Patient and surgeon satisfaction was determined by a visual analogue scale (0-10). Results: There were no significant differences in terms of sedation level, patient and surgeon satisfaction or haemodynamic parameters. Bolus demand and the need for additional fentanyl were higher in the midazolam group (p < 0.05). Conclusions: Propofol is safe and provides good intraoperative conditions and reduces the need for additional fentanyl in ambulatory septoplasty operations.