Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction

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Ertem A. G., Ünal S., Efe T. H., AÇAR B., Yayla Ç., Kuyumcu M. S., ...Daha Fazla

Anatolian Journal of Cardiology, cilt.17, sa.2, ss.119-124, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.14744/anatoljcardiol.2016.7149
  • Dergi Adı: Anatolian Journal of Cardiology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.119-124
  • Anahtar Kelimeler: acute coronary syndrome, adropin, SYNTAX score, SYNTAX SCORE, ENDOTHELIAL FUNCTION, MORTALITY, REVASCULARIZATION, ATHEROSCLEROSIS, INTERVENTION, HOMEOSTASIS, OUTCOMES, TRIAL, FLOW
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2017 by Turkish Society of Cardiology.Objective: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI. Methods: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test. Results: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998–1.000; p=0.007). Conclusion: Adropin could be an alternative blood sample value for predicting severity of CAD.