Prognostic role of pretreatment platelet/lymphocyte ratio in patients with non-small cell lung cancer

Kos M., Hocazade C., Kos F. T., Uncu D., Karakas E., Dogan M., ...Daha Fazla

Wiener Klinische Wochenschrift, cilt.128, sa.17-18, ss.635-640, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 128 Sayı: 17-18
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00508-015-0724-8
  • Dergi Adı: Wiener Klinische Wochenschrift
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.635-640
  • Anahtar Kelimeler: Platelet lymphocyte ratio, Non-small cell lung cancer, Prognosis, PLATELET-LYMPHOCYTE RATIO, NEUTROPHIL-LYMPHOCYTE, COLORECTAL-CANCER, PREDICT SURVIVAL, OVARIAN-CANCER, CHEMOTHERAPY, INFLAMMATION, MARKER, COUNT, PLR
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2015, Springer-Verlag Wien.Background: It was reported that hematological markers of systemic inflammatory response might be prognostic in various cancer types. We aimed to evaluate the platelet/lymphocyte ratio (PLR) as a prognostic factor and its effect on overall survival in non-small cell lung cancer (NSCLC). Methods: Clinicopathological characteristics and basal (pretreatment) PLR of 145 patients with NSCLC were evaluated retrospectively. The preoperative or pretreatment blood count data were obtained from the recorded computerized database. PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. Results: A total of 145 patients were enrolled. Median age was 57 years(range 26–83). Receiver operating characteristic curves for overall survival prediction were plotted to verify the optimum cut-off point for PLR. The recommended cut-off values for PLR was 198.2 with a sensitivity of 65.0 % and a specificity of 71.4 %. Median overall survival was 34.0 (95 % confidence interval (CI) 14.7–53.3) months in the group with low PLR (< 198.2), while it was 11.0 (95 % CI 5.6–16.3) months in the group with high PLR (≥ 198.2). The difference between the groups was statistically significant (p < 0.0001). Conclusions: Our study supports the view that a high basal PLR is a poor prognostic factor in NSCLC. However, the validity of the cut-off values for PLR identified in our study needs further prospective trials.