Akademik Veri Yönetim Sistemi
Journal of Rheumatology and Medical Rehabilitation, cilt.11, sa.3, ss.227-231, 2000 (Scopus)
Continuous ambulatory peritoneal dialysis (CAPD) is an increasingly used form of maintenance dialysis therapy. It has some advantages on hemodialysis (HD), such as there is no need to machine application and dietetic restriction and also permits patient's ambulation during dialysis. Although there is no consensus about the topic, it has been suggested that incidence of neuropathy during CAPD is lower than HD. In this study, ENMG and biochemical analysis of two groups of patients on CAPD and HD program with similar age, dialysis duration and sex distribution were done and compared with each other. Nerve conduction studies, late responses, sympathetic skin responses (SSR) and upper extremity SEP responses were recorded. Mean serum albumin, Hb, Hct and Fe binding capacity was higher, ferritin, cholesterol and LDL was lower in HD group (p < 0.05). Mean peroneal motor and sural sensory distal latency, peroneal F-latency and SSR latency were longer, sural sensory conduction velocity was slower in HD group (p < 0.05). Total ENMG findings demonstrated the existence of a mild axonal neuropathy in both groups. Although these findings suggested that neuropathic process was less severe in DAPD group, the difference was not of such magnitude that one of dialysis forms should be preferred before the other as regards neuropathy. Considering the variability of factors thought to be responsible for pathogenesis of uraemic neuropathy, further studies in larger groups should be carried out to clarify the effect of different dialysis modalities on neuropathic process.