Research with spare embryos achieved by assisted reproductive techniques and remained following embryo transfer has been a subject of debate regarding the ethical issues all over the world. Current developments in science have introduced new approaches for research of assisted reproductive techniques including stem cell, human somatic cell nuclear transfer (cloning) and preimplantation genetic diagnosis which have increased the extent of controversy on ethical dilemma. Current study summarizes the purpose of embryo research, cryopreservation of embryo and regulations of embryo research in different countries. It also mentions the current ethical approach for stem cell research, cloning and preimplantation genetic diagnosis. Finally it explains the present regulations for the ethics of these issues in Turkey concluding with the recommendations that may be useful for the future applications.