Incidence and risk factors of port related infections in patients with hematological malignancy


Yildiz A., Albayrak M., Okutan H., Ergun O., Sahin O., Pala C., ...More

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol.12, no.1, pp.989-996, 2019 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2019
  • Journal Name: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.989-996
  • Keywords: Port, infection, hematological malignancy, neutropenia, CATHETER-RELATED COMPLICATIONS, BLOOD-STREAM INFECTION, VENOUS ACCESS PORTS, CHEMOTHERAPY, SYSTEMS, NEUTROPENIA, DEVICES, COSTS
  • Lokman Hekim University Affiliated: No

Abstract

The aim of this study was to determine the incidence and risk factors of infections associated with implantable venous access ports (IVAPs) in adult patients with hematological cancer. A retrospective analysis was made of patients with hematological malignancies in the adult Hematology Department between December 2014 and December 2016. IVAP was inserted in a total of 87 patients in the Interventional Radiology Department. Evaluation was made of the incidence of port-related infections, patient characteristics, bacteriological data and patient progress. Univariable analyses (Chi-square test and Mann-Whitney U test) and multiple logistic regression analyses were used to determine the risk factors for IVAP-related infection. The study included 87 patients applied with IVAP. There was a total of 21823 catheter/day follow-up. IVAP-related infection was observed in 13 cases (14.9%). Total incidence of IVAP-related bloodstream infections (BSIs) was 0.595 events/1000 catheter days. Coagulase-negative staphylococci were the pathogens most commonly isolated. In logistic regression analysis, factors that increased the risk for IVAP-related infections were neutropenia on the day of implantation (OR = 4.139; P < 0.05) and the number of chemotherapy lines received after IVAP insertion (OR = 2.126; P < 0.05). The median time without IVA-Prelated BSI was 62 days (range, 10-382 days). Neutropenia on the day of implantation and the number of chemotherapy lines after IVAP insertion were independent risk factors for IVAP-related BSIs. Therefore, it can be suggested that, as far as possible, ports should be inserted after the neutropenia period in these patients.