Nociceptin: An endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties


Gumusel B. , Hao Q., Hyman A., Chang J., Kapusta D. R. , Lippton H.

Life Sciences, vol.60, no.8, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 8
  • Publication Date: 1997
  • Doi Number: 10.1016/s0024-3205(96)00696-0
  • Title of Journal : Life Sciences
  • Keywords: orphanin FQ, blood vessels, systemic vasculature, peptide vasorelaxation, cat, PROTEIN-COUPLED RECEPTOR, MOLECULAR-CLONING, GENE FAMILY, TISSUE DISTRIBUTION, CDNA CLONING, MEMBER, LOCALIZATION

Abstract

The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3 x 10-11 - 3 x 10-6 M) decreased tension in a concentration-dependent manner. The present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow.