Atıf İçin Kopyala
Gumusel B., Hao Q., Hyman A., Chang J., Kapusta D. R., Lippton H.
Life Sciences, cilt.60, sa.8, 1997 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
60
Sayı:
8
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Basım Tarihi:
1997
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Doi Numarası:
10.1016/s0024-3205(96)00696-0
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Dergi Adı:
Life Sciences
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Anahtar Kelimeler:
orphanin FQ, blood vessels, systemic vasculature, peptide vasorelaxation, cat, PROTEIN-COUPLED RECEPTOR, MOLECULAR-CLONING, GENE FAMILY, TISSUE DISTRIBUTION, CDNA CLONING, MEMBER, LOCALIZATION
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Lokman Hekim Üniversitesi Adresli:
Hayır
Özet
The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3 x 10-11 - 3 x 10-6 M) decreased tension in a concentration-dependent manner. The present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow.