Akademik Veri Yönetim Sistemi
Doga - Turkish Journal of Medical Sciences, cilt.18, sa.2, ss.135-140, 1993 (Scopus)
For the examination of in vitro glycosylation glucose and sodium azide were added to human sera pools under sterile conditions and incubated at 37°C. This pool is divided into three groups. First group (Group I) was accepted as the control group. Aspirin (acetyl salycylic acid) was added to second (Group II) and third groups (Group III) to produce 30 and 15 mg/dl aspirin levels in samples respectively. We measured fructosamine and malondialdehyde (MDA) levels in these groups. Mean fructosamine level of group I (8.33 ± 4.86 mmol/L) was higher than those of group II (3.89 ± 0.86 mmol/L) and group III (3.97 ± 0.94 mmol/L). Aspirin significantly inhibited the formation of fructosamine during glycosylation period, but it has no inhibitor effect on MDA production. There were no significant difference between MDA levels in three groups (p > 0.05). Nevertheless, there were strong relation between fructosamine and MDA levels for these three groups, their correlation coefficient were 0.71, 0.88, 0.86 respectively. In view of these points it can be said that both fructosamine formation and enolisation of glucose caused the production of MDA. On the other hand can be said that aspirin can not prevent peroxidation. On the contrary, low levels of aspirin can increase peroxidation.