Prevention of intraabdominal adhesions: An experimental study using mitomycin-c and 4% Icodextrin

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Urkan M., ÖZERHAN İ. H., Ünlü A., Can M. F., Öztürk E., Günal A., ...Daha Fazla

Balkan Medical Journal, cilt.34, sa.1, ss.35-40, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/balkanmedj.2015.1359
  • Dergi Adı: Balkan Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.35-40
  • Anahtar Kelimeler: Cecal abrasion, intraabdominal adhesions, mitomycin-C, 4% icodextrin, POSTOPERATIVE ABDOMINAL ADHESIONS, INTRAPERITONEAL ADHESIONS, POSTSURGICAL ADHESIONS, PERITONEAL ADHESIONS, POLYPROPYLENE MESH, STRABISMUS SURGERY, MODEL, BARRIER, TRIAL
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

© 2017 by Trakya University Faculty of Medicine/The Balkan Medical Journal published by Galenos Publishing House.Background: Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations. Aims: We compared the anti-adhesive effects of two different agents on postoperative adhesion formation in a cecal abrasion model. Study Design: Experimental animal study. Methods: Forty Wistar albino type female rats were anesthetized and underwent laparotomy. Study groups comprised Sham, Control, Mitomycin-C, 4% Icodextrin, and Mitomycin-C +4% Icodextrin groups. Macroscopic and histopathological evaluations of adhesions were performed. Results: The frequencies of moderate and severe adhesions were significantly higher in the control group than the other groups. The mitomycin-C and Mitomycin-C +4% Icodextrin groups were associated with significantly lower adhesion scores compared to the control group and 4% Icodextrin group scores (p=0.002 and p=0.008, respectively). The adhesion scores of the Mitomycin-C group were also significantly lower than those of the 4% Icodextrin group (p=0.008). Conclusion: Despite its potential for bone marrow toxicity, Mitomycin-C seems to effectively prevent adhesions. Further studies that prove an acceptable safety profile relating to this promising anti-adhesive agent are required before moving into clinical trials.