ADVANTAGES OF HOMEOPATHIC LICORICE-BASED NANOMEDICINES AS NOVEL THERAPEUTIC MATERIALS


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Madatli F., Musayeva S., Valiyeva M., Atakishizada S., Ahmadian E., Erdoğan Orhan İ.

New Materials Compounds and Applications, cilt.7, sa.2, ss.59-75, 2023 (ESCI)

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 7 Sayı: 2
  • Basım Tarihi: 2023
  • Dergi Adı: New Materials Compounds and Applications
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.59-75
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Licorice (Glycyrrhiza glabra L.) is renowned for its traditional medicinal and homeopathic applications against numerous diseases. As the main triterpenoid compound derived from licorice extract, glycyrrhizin (GL) has been identified to possess wide-ranging pharmacological effects. GL is hydrolyzed into its aglycone glycyrrhetinic acid (GA) and glucuronide. In addition, flavonoids such as isoliquiritigenin are found in licorice roots. It is well documented that these active components exhibit great potential as anticancer, anti-inflammatory, hepatoprotective, antimicrobial, and antioxidant agents, in particular. However, their poor water solubility, low bioavailability in biological fluids, and possible cytotoxicities hinder their clinical uses. Nanomedicine has opened a new avenue in this context and augmenting the bioavailability and safety of these herbal drugs can aid in developing suitable agents for clinical application. The current review summarizes recent advances in the production of novel licoricebased nanoformulations for the treatment of different illnesses. Various therapeutic effects have been observed in licorice-based nanomedicines including antibacterial, immuno-modulatory, antiinflammatory, hepatoprotective, regenerative, and drug delivery. The current manuscripts summarized the role of nanomedicine in enhancing the pharmacological effects of licorice-based beneficial agents by providing targeted delivery of more bioavailable products. The application of nanotechnology in the fabrication of licorice-based products can potentially alleviate most of the pathologies and also reduce the toxicity of therapeutic strategies.